The opportunity
Natera is seeking a Lead Bioinformatics Scientist to join our Oncology Bioinformatics team and support the development, validation, and clinical application of our NGS-based assays. The ideal candidate has a strong background in data analysis for wet lab support and extensive…
What you'll do
Lead the analytical validation strategy for an NGS-based assay, including: designing, analyzing, and troubleshooting feasibility and performance evaluation studies (e.g., PPA and LoD) with bench scientists and biostatisticians.
Drive real-world evidence (RWE) studies that demonstrate the clinical utility: of for therapy selection and patient management, from cohort selection through analysis of plasma mutation calls.
Build rapid prototypes and pipelines for custom analyses that integrate data from multiple Natera products.
Develop algorithms and tools to support new products, including contributions: to the production bioinformatics pipeline.
Act as an internal technical consultant on bioinformatics methodology for other functional groups.
Work closely with assay development, engineering, biostatistics, clinical,: commercial, regulatory, and lab operations teams.
What they're looking for
- Contribute to regulatory submissions, clinical study reports, and scientific publications.
- Master’s degree in bioinformatics (or a related field) with 10 years of: post-graduate experience, or PhD with 5 years of post-graduate experience (preferred).
- Expert knowledge of bioinformatics tools for NGS, including sequencing QC and: secondary analysis such as variant calling.
- Experience with WES/WGS/targeted sequencing of tissue and cfDNA, and with: somatic variant calling (SNVs, indels, CNVs, fusions) on these data.